Brønsted acid-catalyzed Mannich reaction through dual activation of aldehydes and N-Boc-imines.
نویسندگان
چکیده
In the presence of a Brønsted acid catalyst, both aldehydes and N-Boc-aminals were converted to enecarbamates and N-Boc-iminium salts as activated nucleophiles and electrophiles, respectively, giving unprecedented Mannich adducts. The asymmetric variant of the present Mannich reaction has also been demonstrated with a chiral phosphoric acid catalyst.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 92 شماره
صفحات -
تاریخ انتشار 2015